Volume : 08, Issue : 10, October – 2021

Title:

17.FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF METOCLOPROMIDE HCL USING NATURAL AND SYNTHETIC SUPER DISINTEGRANTS

Authors :

Abdul Sayeed, Dr. Pawan Kumar, Dr. Syed Areefulla Hussainy

Abstract :

In the present study, formulation of mouth dissolving tablets for anti emetic drug using natural and synthetic super disintegrants by direct compression method. In the direct compression method, Plantago ovate mucilage (2-8%) was used as natural super disintegrants, Cross carmellose sodium (2-8%) was used as synthetic super disintegrants. Estimation of anti emetic drug in the prepared tablet formulations was carried out by extracting the drug with 0.1 N HCL and pH 6.8 phosphate buffer and measuring the absorbance at 272.6nm.
The prepared formulations were further tested for post compression parameters.
In vitro drug release pattern (0.1 N HCL and pH 6.8 phosphate buffer), stability study (at 40ºC/ 75% RH for 6 months), drug-excipient interaction (IR spectroscopy) in vitro dispersion time respectively in comparison with formulations containing natural super disintigrant.
The promising formulations containing 8% w/w natural super disintegrant Plantago ovata mucilage emerged as the overall best formulation formulations (FM8).
Short-term stability studies of promising formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05). IR-spectroscopic studies indicated that there are no drug-excipient interactions. It can be concluded from the present work that natural super disintegrant were found to be superior in compression with synthetic super disintegrate with improved dissolution.
Keywords: Metoclopramide HCL, Plantago ovata mucilage, Cross carmellose sodium.

Cite This Article:

Please cite this article in press Abdul Sayeed et al, Formulation And Evaluation Of Mouth Dissolving Tablets Of Metoclopromide Hcl Using Natural And Synthetic Super Disintegrants., Indo Am. J. P. Sci, 2021; 08(10)..

Number of Downloads : 10

References:

1. Shah S, Madan S and Agrawal SS. Formulation and evaluation of microsphere based oro dispersible tablets of Itopride HCl. DARU J pharmsci, 20(24) (2012) 1-12.
2. Bharathi A, Ramakrishna V. Formulation development and in-vitro evaluation of orally disintegrating tablets of Amlodipine besylate. IJRPC, (2012) 1029-34.
3. Debjit Bhowmik, Chiranjib.B, Krishnakanth, Pankaj, Margret Chandra.R. Fast dissolving tablets. Journal of Chemical & Pharmaceuticeutical Research, 2009; 1(1): 163-177.
4. Malla VC, Mani Kumari M, Mariyadas U, Sushma M, Mounika N. Formulation and Evaluation of Ibuprofen Tablets by using different superdisintegrating agents. World J Pharm Pharm Sci 2016;5(5):875-883.
5. Dali shukla, Subhashis Chakraborty, Sanjay Singh, Brahmeshwarn Mishra.Mouth dissolving tablets: an overview of formulation technology.2009, 77:309- 326.
6. Tapan kumar, Dulal Krishna, Rana.Formulation aspects in the development of Orodispersible tablets: an overview. International journal of pharmacy and Pharmaceutical sciences, 2010: May 07:2(3).
7. Tejvir, Bhavandeep , Sandeep ,Gupta GD. Mouth dissolving tablets; A novel approach to drug delivery. International journal of current pharmaceutical research.2011:July 17:3(1).
8. Pagar R, Ahirrao S, Yallatikar T, Wagh M. Rev on orodispersible tablets. Int J Res Dev Pharm L Sci 2014;3:949-58.
9. Mishra S, Prajapati K, Bhardwaj P. A rev on formulation and evaluation for mouth dissolving tablet. World J Pharm PharmSci 2014;8:1778-810.
10. Kuchekar S, Badha C, Mahajan S. Mouth dissolving tablets. A novel drug del system. Pharm times 2003; 35:7-9.
11. Kumaran K, Sreekanth J, Palanisamy S. Formulation, development and evaluation of Levodopa-Carbidopa orally disintegration tablets. J Chem Pharm Res 2011; 3(3):169-175.
12. Belet H, Derle V. Analysis of patents pertaining to superdisintegrants used in tablet manufacturing. J intellectual Property Rights 2008;13:601-604.
13. Omidian H, Park K. Swelling agents and devices in oral drug delivery. J Drug Del Sci Tech 2008;18(2):83-93.
14. Bhardwaj S, Jain V, Sharma S, Jat RC, Jain S. Orally disintegrating tablets. A rev Drug Invention Today 2010;2(1):81-88.