Volume : 09, Issue : 01, January – 2022

Title:

17.FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF KETOROLAC TROMETHAMINE

Authors :

M. K. Rekha*

Abstract :

Among the various routes of drug delivery, the oral route is perhaps the most preferred by patients and clinicians alike. Ketorolac is currently administered intramuscularly (30 mg) and orally as conventional tablet (10 mg) for short-term management of post-operative pain and moderate to severe pain. It is a non-steroidal anti-inflammatory cyclooxygenase inhibitor. It acts by inhibiting the synthesis of prostaglandins. The major side effects of Ketorolac are gastric mucosal erosions, ulcers and gastric bleeding. The aim of this study was to prepare a new mucoadhesive tablet formulation of Ketorolac Tromethamine in view of attaining prolonged effect of drug for better therapy with reduced dosing frequency.
In present work, an attempt has been made to formulate buccoadhesive tabletof model drug and preparation of tablets using hydrophilic polymers like HPMC K15M, HPMC K4M and carbopol934.
The buccal tablets were characterized on the basis of their physical parameters (hardness, thickness, weight variation) drug content, surface pH, swelling index, mucoadhesive strength, in vitro drug release were studied.
Key words: Ketorolac Tromethamine, non-steroidal anti-inflammatory, mucoadhesive tablet, HPMC K15M, HPMC K4M and carbopol934.

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Cite This Article:

Please cite this article in press M.K.Rekha., Formulation And Evaluation Of Mucoadhesive Buccal Tablets Of Ketorolac Tromethamine., Indo Am. J. P. Sci, 2022; 09(01).

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References:

1. Harries D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci 1992; 81:1-10.
2. KharRK,AhujaA,AliJ.MucoadhesiveDrugDelivery.In:N.K.Jain.,editor.Controlled and Novel Drug Delivery. 1997 ed. Sagar: CBS Publishers and Distributors; 2002: p. 353.
3. Manuchair Ebadi. Desk reference of clinical pharmacology. Second edition: Manuchair publication; 2008:p.375
4. Jain NK. Controlled and novel drug delivery. 1st edition, New delhi CBS publishers and distributors 1997:p.354.
5. Perioli L, Ambrogiv V, Stefano G, Ricci M, Blasi P, Carlo R. Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen. AAPS Pharm SciTech 2007; 8(3):E1-E6.
6. Derle D, Joshi O, Pawar A, Patel J, Amol J. Formulation and evaluation of buccoadhesive bi-layer tablet of propranolol hydrochloride. Int J Pharm Pharma Tech 2009; 1(1):206-212.
7. Manivannan R, Balasubramaniam, Premanand DC, Sandeep G, Rajkumar N. Formulation and In-Vitro Evaluation of Mucoadhesive Buccal Tablets of Diltiazem Hydrochloride. Research J Pharm and Tech.2008;1(4):478-80.
8. Gerbino PP. Remington: The science and practice of pharmacy. 21st ed.Philadelphia: PA. Lippincott Williams & Wilkins; 2005. P.916-18.
9. United States Pharmacopoeia, 30-National Formulary 25. 2007. P 242, 378, 643, 731.
10. Prasad BK, Remeth JD, Kailas KM, Vijay DH, Niranjan SM.Formulation and evaluation of buccoadhesive tablets of atenolol. J Pharm Res 2008; 1 (2): 193-9.
11. Desai KGH, Kumar TMP. Preparation and Evaluation of a novel buccal adhesive systems. AAPS Pharm SciTech 2004; 5(3):1-9.
12. Madgulkar A, Bhalekar M, Wable N, Patel K, Kolhe V. Egg shell membrane as substrate for bioadhesion measures. Indian Drugs 2008; 45(3):219-21.
13. Deshmukh VN, Jadhav JK, Sakarkar DM. Formulation and in-vitro Evaluation of theophylline anhydrous bioadhesive tablets. Asian J 2009; 3(1):54-8.
14. Choi HG, Kim CK. Development of omeprazole buccal adhesive tablets with stability enhancement in human saliva. J contro Rele 2000; 68:397-404.
15. Shindhaye SS, Thakkar PV, Dand NM, Kadak VJ. Buccal drug delivery of pravastatin sodium. AAPS Pharm SciTech 2010; 11(1):416-23.
16. Patel VM, Bhupendra GP, Patel HV, Patel KM. Mucoadhesive bilayer tablets of propranolol hydrochloride. AAPS Pharm SciTech 2007; 8(3):E1-E6.
17. Nakhat PD, Babla IB, Khan S, Rathi SG, Ghule BV, Yeole PG. Design and characterization of buccodhesive tablets of promethazine hydrochloride. Indian Drugs 2007; 44(7):520-6.
18. Ananda Reddy K and Venugopal K. Formulation and in vitro evaluation of buccal tablets of piroxicam. Int J Chem. Sci.2012;10(1):399-412