Volume : 09, Issue : 11, November – 2022
Title:
38.DESIGN PREPARATION AND APPLICATIONS OF MAGNETIC NANOPARTICLES
Authors :
K.Bharath *, V.Sai kishore
Abstract :
Magnetic nano particles are of great interest for researchers from a wide range of disciplines, including magnetic fluids in biotechnology/biomedicine, magnetic resonance imaging and environmental remediation. While a number of suitable methods have been developed for the synthesis of magnetic nano particles of various different compositions, successful application of such magnetic nano particles in the areas listed above is highly dependent on the stability of the particles under a range of different conditions. In the present review, first we have briefly discussed main synthetic methods of MNPs, followed by their characterizations and composition. Then we have discussed the potential applications of MNPs in different with representative examples. At the end, we gave an overview on the current challenges and future prospects of MNPs. We focus mainly on recent developments in the synthesis of magnetic nanoparticles, and various strategies for the protection of the particles against oxidation and acid erosion. Further functionalization and application of such magnetic nanoparticles in catalysis and bio separation will be discussed in brief. This comprehensive review not only provides the mechanistic insight into the synthesis, functionalization, and application of MNPs but also outlines the limits and potential prospects.
Key Words: Magnetic nanoparticles, iron oxide ,magnetite , Hyperthermia
Cite This Article:
Please cite this article in press K.Bharath et al, Design Preparation And Applications Of Magnetic Nanoparticles.,Indo Am. J. P. Sci, 2022; 09(11).
Number of Downloads : 10
References:
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22. Remsen LG, McCormick CI, Roman-Goldstein S, Nilaver G, Weissleder R, Bogdanov A, Hellström I, Kroll RA, Neuwelt EA. MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis. AJNR Am. J. Neuroradiol. 1996, 17, 411–418
23.Alexiou C, Arnold W, Klein RJ, Parak FG, Hulin P, Bergemann C, Erhardt W, Wagenpfeil S, Lübbe AS. Locoregional cancer treatment with magnetic drug targeting. Cancer Res. 2000, 60, 6641–6648.
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26.Chen J, Wu H, Han D, Xie C. Using anti-VEGF McAb and magnetic nanoparticles as double-targeting vector for the radioimmunotherapy of liver cancer. Cancer Lett. 2006, 231, 169–175.
27.Li XS, Li WQ, Wang WB. Using targeted magnetic arsenic trioxide nanoparticles for osteosarcoma treatment. Cancer Biother. Radiopharm. 2007, 22, 772–778.
28.Johannsen M, Gneveckow U, Thiesen B, Taymoorian K, Cho CH, Waldöfner N, Scholz R, Jordan A, Loening SA, Wust P. Thermo- therapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution. Eur. Urol. 2007, 52, 1653–1661
29. DeNardo SJ, DeNardo GL, Natarajan A, Miers LA, Foreman AR, Gruettner C, Adamson GN, Ivkov R. Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF – induced thermoablative therapy for human breast cancer in mice.J. Nucl. Med. 2007, 48, 437–444.
30. Li Z, Xiang J, Zhang W, Fan S, Wu M, Li X, Li G. Nanoparticle delivery of anti-metastatic NM23-H1 gene improves chemotherapy in a mouse tumor model. Cancer Gene Ther. 2009, 16, 423–429.
31.Balivada S, Rachakatla RS, Wang H, Samarakoon TN, Dani RK, Pyle M, Kroh FO, Walker B, Leaym X, Koper OB, Tamura M, Chikan V, Bossmann SH, Troyer DL. A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study. BMC Cancer 2010, 10, 119.
32.Bruners P, Braunschweig T, Hodenius M, Pietsch H, Penzkofer T, Baumann M, Günther RW, Schmitz-Rode T, Mahnken AH. Thermoablation of malignant kidney tumors using magnetic nanoparticles: an in vivo feasibility study in a rabbit model. Cardiovasc. Intervent. Radiol. 2010, 33, 127–134.
33.Fang C, Veiseh O, Kievit F, Bhattarai N, Wang F, Stephen Z, Li C, Lee D, Ellenbogen RG, Zhang M. Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physico- chemical properties and in vivo behavior. Nanomedicine (Lond) 2010, 5, 1357–1369.
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37. Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H, Budach V, Jordan A. Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxidena noparticles combined with external beam radiotherapy onpatients with recurrent glioblastoma multiforme. J. Neurooncol.
2011, 103, 317–324.
38. Agemy L, Friedmann-Morvinski D, Kotamrajua VR, Sugahar RL, Girard OM, Mattrey RF, Verma IM, Ruoslahti E. Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc. Natl. Acad. Sci. USA 2011, 108, 17450–17455.
39. Dutz S, Kettering M, Hilger I, Müller R, Zeisberger M. Magnetic multicore nanoparticles for hyperthermia-influence of particle immobilization in tumour tissue on magnetic properties. Nanotechnology 2011, 22: 265102-111.
40. Plank C, Zelphati O, Mykhaylyk O. Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects. Adv. Drug Deliv. Rev. 2011, 63, 1300–1331.
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42. Tang QS, Chen DZ, Xue WQ, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S, Xiang JY, Gong YC, Zhang L, Guo CQ. Preparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-folate-CDDP/HSA MNPs) in vivo. Int. J. Nanomed. 2011, 6, 3077–3085.
43. Toraya-Brown S, Sheen MR, Baird JR, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S. Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy. Integr. Biol. (Camb) 2013, 5, 159–171.
44. Russell, E., Dunne, V., Russell, B. et al. Impact of superparamagnetic iron oxide nanoparticles on in vitro and in vivo radiosensitisation of cancer cells. Radiat Oncol 2021;16: 104-113.
45. Amatya, R.; Hwang, S.; Park, T.; Min, K.A.; Shin, M.C. In Vitro and In Vivo Evaluation of PEGylated Starch-Coated Iron Oxide Nanoparticles for Enhanced Photothermal Cancer Therapy. Pharmaceutics 2021;13:871-885.
2.Ling, W.H.; Wang, M.Y.; Xiong, C.X.; Xie, D.F.; Chen, Q.Y.; Chu, X.Y.; Qiu, X.Y.; Li, Y.M.; Xiao, X. Synthesis, surface modification, and applications of magnetic iron oxide nanoparticles. J. Mater. Res. 2019, 34, 1828–1844.
3.Pal SL, Jana U, Manna PK, Mohanta GP, Manavalan R. Nanoparticle: an overview of preparation and characterization. J Appl Pharm Sci 2011;1:228-34.
4.Hasany SF, Ahmed I, Rajan J, Rehman A. Systematic review of the preparation techniques of iron oxide magnetic nanoparticles. Nanosci Nanotechnol 2012;2:148-58.
5. Rangarajan M, Vasanthakumari R, Vikram S. Superparamagnetic iron oxide nanoparticles from coprecipitation: composition, size, and magnetization. Nanosci Nanotechnol 2014;14:1-9.
6. Faraji M, Yamini Y, Rezaee M: Magnetic nanoparticles: synthesis, stabilization, functionalization, characterization and applications. J Iran Chem Soc 2010, 7(1):1-37.
7. Lu AH, Salabas EL, Schuth F: Magnetic nanoparticles: Synthesis, protection, functionalization, and application. Angew Chem Int Ed 2007, 46(8):1222-1244.
8. Dutz, S.; Andrä, W.; Hergt, R.; Müller, R.; Oestreich, C.; Schmidt, C.; Töpfer, J.; Zeisberger, M.; Bellemann, M.E. Influence of Dextran Coating on the Magnetic Behaviour of Iron Oxide Nanoparticles. J. Magn. Magn. Mater. 2007, 311, 51–54.
9. Blanco-Andujar, C.; Ortega, D.; Southern, P.; Pankhurst, Q.A.; Thanh, N.T.K. High Performance Multi-core Iron Oxide Nanoparticles for Magnetic Hyperthermia: Microwave Synthesis, and the Role of Core-to-Core Interactions. Nanoscale 2015, 7, 1768–1775
10. Okoli, C.; Sanchez-Dominguez, M.; Boutonnet, M.; Jaras, S.; Civera, C.; Solans, C.; Kuttuva, G.R. Comparison and Functionalization Study of Microemulsion-Prepared Magnetic Iron Oxide Nanoparticles. Langmuir 2012, 28, 8479–8485
11. Laurent, S.; Forge, D.; Port, M.; Roch, A.; Robic, C.; Elst, L.V.; Müller, R.N. Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications. Chem. Rev. 2008, 108, 2064–2110.
12. Reddy, L.H.; Arias, J.L.; Nicolas, J.; Couvreur, P. Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications. Chem. Rev. 2012, 112, 5818–5878.
13. Sun, S.; Zeng, H. Size-Controlled Synthesis of Magnetite Nanoparticles. J. Am. Chem. Soc. 2002, 124, 8204–8205.
14. Park, J.; Lee, E.; Hwang, N.M.; Kang, M.S.; Kim, S.C.; Hwang, Y.; Park, J.G.; Noh, H.J.; Kini, J.Y.; Park, J.H.; et al. One-nanometer-scale size-controlled synthesis of monodisperse magnetic iron oxide nanoparticles. Angew. Chem. Int. Ed. 2005, 44, 2872–2877.
15. Boddolla S, Thodeti S. A review on characterization techniques of nanomaterials. Int J Eng Sci Mathematics 2018;7:169-75.
16. Blanco-Andujar, C.; Ortega, D.; Southern, P.; Pankhurst, Q.A.; Thanh, N.T.K. High Performance Multi-core Iron Oxide Nanoparticles for Magnetic Hyperthermia: Microwave Synthesis, and the Role of Core-to-Core Interactions. Nanoscale 2015, 7, 1768–1775.
17. Faraji, M.; Yamini, Y.; Rezaee, M. Magnetic Nanoparticles: Synthesis, Stabilization, Functionalization, Characterization, and Applications. J. Iran. Chem. Soc. 2010, 7, 1–37.
18. Khandhar, A.P.; Keselman, P.; Kemp, S.J.; Ferguson, R.M.; Goodwill, P.W.; Conolly, S.M.; Krishnan, K.M. Evaluation of PEG-coated iron oxide nanoparticles as blood pool tracers for preclinical magnetic particle imaging. Nanoscale 2017, 9, 1299–1306.
19. Chen, Y.; Xiong, Z.; Zhang, L.; Zhao, J.; Zhang, Q.; Peng, L.; Zhang, W.; Ye, M.; Zou, H. Facile synthesis of zwitterionic polymer-coated core-shell magnetic nanoparticles for highly specific capture of N-linked glycopeptides. Nanoscale 2015, 7, 3100–3108.
20.Olivia L. Lanier, Olena I. Korotych, Adam G. Monsalve, Dayita Wable, Shehaab Savliwala, Noa W. F. Grooms, Christopher Nacea, Omani R. Tuitt & Jon Dobson . Evaluation of magnetic nanoparticles for magnetic fluid hyperthermia, International Journal of Hyperthermia,2019; 36(1): 687-701.
21. Rainov NG, Zimmer C, Chase M, Chase M, Kramm CM, Chiocca EA, Weissleder R, Breakefield XO. Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms. Hum. Gene Ther. 1995, 6, 1543–1552.
22. Remsen LG, McCormick CI, Roman-Goldstein S, Nilaver G, Weissleder R, Bogdanov A, Hellström I, Kroll RA, Neuwelt EA. MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis. AJNR Am. J. Neuroradiol. 1996, 17, 411–418
23.Alexiou C, Arnold W, Klein RJ, Parak FG, Hulin P, Bergemann C, Erhardt W, Wagenpfeil S, Lübbe AS. Locoregional cancer treatment with magnetic drug targeting. Cancer Res. 2000, 60, 6641–6648.
24.Hilger I, Hiergeist R, Hergt R, Winnefeld K, Schubert H, Kaiser WA. Thermal ablation of tumors using magnetic nanoparticles: an in vivo feasibility study. Invest. Radiol. 2002, 37, 580–586
25. Tanaka K, Ito A, Kobayashi T, Kawamura T, Shimada S, Matsumoto K, Saida T, Honda H. Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles. Int. J. Cancer2005, 116, 624–633.
26.Chen J, Wu H, Han D, Xie C. Using anti-VEGF McAb and magnetic nanoparticles as double-targeting vector for the radioimmunotherapy of liver cancer. Cancer Lett. 2006, 231, 169–175.
27.Li XS, Li WQ, Wang WB. Using targeted magnetic arsenic trioxide nanoparticles for osteosarcoma treatment. Cancer Biother. Radiopharm. 2007, 22, 772–778.
28.Johannsen M, Gneveckow U, Thiesen B, Taymoorian K, Cho CH, Waldöfner N, Scholz R, Jordan A, Loening SA, Wust P. Thermo- therapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution. Eur. Urol. 2007, 52, 1653–1661
29. DeNardo SJ, DeNardo GL, Natarajan A, Miers LA, Foreman AR, Gruettner C, Adamson GN, Ivkov R. Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF – induced thermoablative therapy for human breast cancer in mice.J. Nucl. Med. 2007, 48, 437–444.
30. Li Z, Xiang J, Zhang W, Fan S, Wu M, Li X, Li G. Nanoparticle delivery of anti-metastatic NM23-H1 gene improves chemotherapy in a mouse tumor model. Cancer Gene Ther. 2009, 16, 423–429.
31.Balivada S, Rachakatla RS, Wang H, Samarakoon TN, Dani RK, Pyle M, Kroh FO, Walker B, Leaym X, Koper OB, Tamura M, Chikan V, Bossmann SH, Troyer DL. A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study. BMC Cancer 2010, 10, 119.
32.Bruners P, Braunschweig T, Hodenius M, Pietsch H, Penzkofer T, Baumann M, Günther RW, Schmitz-Rode T, Mahnken AH. Thermoablation of malignant kidney tumors using magnetic nanoparticles: an in vivo feasibility study in a rabbit model. Cardiovasc. Intervent. Radiol. 2010, 33, 127–134.
33.Fang C, Veiseh O, Kievit F, Bhattarai N, Wang F, Stephen Z, Li C, Lee D, Ellenbogen RG, Zhang M. Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physico- chemical properties and in vivo behavior. Nanomedicine (Lond) 2010, 5, 1357–1369.
34. Kumar M, Yigit M, Dai G, Moore A, Medarova Z. Image-guided breast tumor therapy using a small interfering RNA nanodrug. Cancer Res. 2010, 70, 7553–7561.35. Shen LF, Chen J, Zeng S, Zhou RR, Zhu H, Zhong MZ, Yao RJ, Shen H. The superparamagnetic nanoparticles carrying the E1A gene enhance the radiosensitivity of human cervical carcinoma in nude mice. Mol. Cancer Ther. 2010, 9, 2123–2130.
36. Tresilwised N, Pithayanukul P, Mykhaylyk O, Holm PS, Holzmüller R, Anton M, Thalhammer S, Adigüzel D, Döblinger M, Plank C. Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force. Mol. Pharm. 2010, 7, 1069–1089.
37. Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H, Budach V, Jordan A. Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxidena noparticles combined with external beam radiotherapy onpatients with recurrent glioblastoma multiforme. J. Neurooncol.
2011, 103, 317–324.
38. Agemy L, Friedmann-Morvinski D, Kotamrajua VR, Sugahar RL, Girard OM, Mattrey RF, Verma IM, Ruoslahti E. Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc. Natl. Acad. Sci. USA 2011, 108, 17450–17455.
39. Dutz S, Kettering M, Hilger I, Müller R, Zeisberger M. Magnetic multicore nanoparticles for hyperthermia-influence of particle immobilization in tumour tissue on magnetic properties. Nanotechnology 2011, 22: 265102-111.
40. Plank C, Zelphati O, Mykhaylyk O. Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects. Adv. Drug Deliv. Rev. 2011, 63, 1300–1331.
41. Tang QS, Chen DZ, Xue WQ, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S, Xiang JY, Gong YC, Zhang L, Guo CQ. Preparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-folate-CDDP/HSA MNPs) in vivo. Int. J. Nanomed. 2011, 6, 3077–3085.
42. Tang QS, Chen DZ, Xue WQ, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S, Xiang JY, Gong YC, Zhang L, Guo CQ. Preparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-folate-CDDP/HSA MNPs) in vivo. Int. J. Nanomed. 2011, 6, 3077–3085.
43. Toraya-Brown S, Sheen MR, Baird JR, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S. Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy. Integr. Biol. (Camb) 2013, 5, 159–171.
44. Russell, E., Dunne, V., Russell, B. et al. Impact of superparamagnetic iron oxide nanoparticles on in vitro and in vivo radiosensitisation of cancer cells. Radiat Oncol 2021;16: 104-113.
45. Amatya, R.; Hwang, S.; Park, T.; Min, K.A.; Shin, M.C. In Vitro and In Vivo Evaluation of PEGylated Starch-Coated Iron Oxide Nanoparticles for Enhanced Photothermal Cancer Therapy. Pharmaceutics 2021;13:871-885.