Volume : 10, Issue : 03, March – 2023
Title:
18.DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP HPLC METHOD FOR THE DETERMINATION OF ULIPRISTAL ACETATE IN PHARMACEUTICAL DOSAGE FORMS
Authors :
Devanpally Rajashekhar, Dr k. Balaji
Abstract :
A simple and selective LC method is described for the determination of Ulipristal in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Phosphate buffer(KH2PO4) pH4.0: Acetonitrile (30:70v/v/v),with detection of 223 nm. Linearity was observed in the range 60-140 µg /ml for Ulipristal (r2 =0.999) for drugs estimated by the proposed methods was in good agreement with the label claim. From the above experimental results and parameters it was concluded that, this newly developed method for the simultaneous estimation of Ulipristal was found to be simple, precise, accurate and high resolution and shorter retention time makes this method more acceptable and cost effective and it can be effectively applied for routine analysis in research institutions, quality control department in meant in industries, approved testing laboratories, bio-pharmaceutical and bio-equivalence studies and in clinical pharmacokinetic studies in near future.
Keywords: Ulipristal, RP-HPLC, Development, Validation
Cite This Article:
Please cite this article in press Devanpally Rajashekhar et al, Development And Validation Of Stability Indicating RP HPLC Method For The Determination Of Ulipristal Acetate In Pharmaceutical Dosage Forms .,Indo Am. J. P. Sci, 2023; 10(03).
Number of Downloads : 10
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