Please cite this article in press Feba G et al,. A Review On Evaluation Of Caffeine Content From Different Brands Of Marketed Tea Powder., Indo Am. J. P. Sci, 2023; 10 (05).

1. Nehlig A, Daval JL, Debry G(1992). “caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”. Brain research. Brain research reviews. 17(2): 139-170.
2. Camfield DA, Stough C, Farrimond J, Scholey AB (August 2014). “acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-anlaysis”. Nutrition reviews. 72(8): 507-522.
3. Wood S, Sage JR, Shuman T, Anagnostaras SG (January 2014). “psychostimulants and cognition: a continuum of behavioral and cognition activation”. Pharmacological reviews.66(1): 193-221.
4. Ribeiro JA, Sebastião AM (2010). “Caffeine and adenosine”. Journal of alzheimers disease.20 (suppl 1): S3-15.
5. Hillis DM, Sadava D, Hill RW, Price MV (2015). Principles of life (2 ed.). pp. 102-103.
6. Faudone G, Arifi S, Merk D (June 2021). “The medicinal chemistry of caffeine”. Journal of medicinal chemistry. 64(11): 7156-7178.
7. Caballero B, Finglas P, Toldra F (2015). Encyclopedia of food and health. Elseiver Science. P. 561.
8. Myers RL (2007). The 100 most important chemical compounds: A Reference Guide.
9. Wright GA, Baker DD, Palmer MJ, Stabler D, Mustard JA, Power EF, Borland
AM, Stevenson PC(March 2013). “Caffeine in floral nectar enhances a pollinator’s memory of reward”.Science.339(6124): 1202-4.
10. “Global coffee consumption, 2020/21”.
11. Burchfield G (1997). Meredith H (ed.). “What’s your poison: caffeine”.
12. Jamieson RW(2001). “the essence of commodification: caffeine dependencies in the early modern world”. Journal of social history. 35(2): 269-294.
13. WHO Model List of essential medicines (PDF)(18th ed.). World Health Organisation. October 2013(April 2013). P. 34 [p. 38 of pdf]. Archived (PDF) from the original on 23 April 2014. Retrieved 23 december 2014.
14. Cano-Marquina A, Tarín JJ, Cano A (May 2013). “The impact of coffee on health”
15. Qi H, Li S (April 2014). “Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson’s disease”. Geriatrics & Gerontology International. 14 (2): 430–9.
16. O’Callaghan F, Muurlink O, Reid N (7 December 2018). “Effects of caffeine on sleep quality and daytime functioning”. Risk Management and Healthcare Policy. 11: 263–271.
17. Jahanfar S, Jaafar SH, et al. (Cochrane Pregnancy and Childbirth Group) (June 2015). “Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcomes”. The Cochrane Database of Systematic Reviews (6): CD006965.
18. American College of Obstetricians and Gynecologists (August 2010). “ACOG CommitteeOpinion No. 462: Moderate caffeine consumption during pregnancy”. Obstetrics and Gynecology. 116 (2 Pt 1): 467–8.
19. Malenka RC, Nestler EJ, Hyman SE (2009). “Chapter 15: Reinforcement and Addictive Disorders”. In Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 375. ISBN 978-0-07-148127-4. Long-term caffeine use can lead to mild physical dependence. A withdrawal syndrome characterized by drowsiness, irritability, and headache typically lasts no longer than a day. True compulsive use of caffeine has not been documented.
20. American Psychiatric Association (2013). “Substance-Related and Addictive Disorders” (PDF). American Psychiatric Publishing. pp. 1–2. Archived from the original (PDF) on 15 August 2015. Retrieved 10 July 2015. Substance use disorder in DSM-5 combines the DSM-IV categories of substance abuse and substance dependence into a single disorder measured on a continuum from mild to severe. … Additionally, the diagnosis of dependence caused much confusion. Most people link dependence with “addiction” when in fact dependence can be a normal body response to a substance. … DSM-5 will not include caffeine use disorder, although research shows that as little as two to three cups of coffee can trigger a withdrawal effect marked by tiredness or sleepiness. There is sufficient evidence to support this as a condition, however it is not yet clear to what extent it is a clinically significant disorder.
21. Juliano LM, Griffiths RR (October 2004). “A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features”. Psychopharmacology. 176 (1): 1–29. doi:10.1007/s00213004-2000-x. PMID 15448977. S2CID 5572188. Results: Of 49 symptom
categories identified, the following 10 fulfilled validity criteria: headache, fatigue, decreased energy/ activeness, decreased alertness, drowsiness, decreased contentedness, depressed mood, difficulty concentrating, irritability, and foggy/not clearheaded. In addition, flu-like symptoms, nausea/vomiting, and muscle pain/stiffness were judged likely to represent valid symptom categories. In experimental studies, the incidence of headache was 50% and the incidence of clinically significant distress or functional impairment was 13%. Typically, onset of symptoms occurred 12–24 h after abstinence, with peak intensity at 20–51 h, and for a duration of 2–9 days.
22. Robertson D, Wade D, Workman R, Woosley RL, Oates JA (April 1981). “Tolerance to the humoral and hemodynamic effects of caffeine in man”. The Journal of Clinical Investigation. 67 (4): 1111–7.
23. Heckman MA, Weil J, Gonzalez de Mejia E (April 2010). “Caffeine (1, 3, 7trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters”. Journal of Food Science. 75 (3):
R77–R87
24. EFSA Panel on Dietetic Products, Nutrition and Allergies (2015). “Scientific Opinion on the safety of caffeine”. EFSA Journal. 13 (5): 4102.
25. Awwad S, Issa R, Alnsour L, Albals D, Al-Momani I (December 2021). “Quantification of Caffeine and Chlorogenic Acid in Green and Roasted Coffee Samples Using HPLC-DAD and Evaluation of the Effect of Degree of Roasting on Their Levels”. Molecules. 26 (24): 7502.
26. “Caffeine”. Pubchem Compound. NCBI. Retrieved 16 October 2014.
Boiling Point 178 °C (sublimes)
Melting Point 238 DEG C (ANHYD)
27. “Caffeine”. ChemSpider. Royal Society of Chemistry. Archived from the original on 14 May 2019. Retrieved 16 October 2014. Experimental Melting Point:
234–236 °C Alfa Aesar 237°C Oxford University Chemical Safety Data 238°C LKT Labs [C0221]
237°C Jean-Claude Bradley Open Melting Point Dataset 14937
238°C Jean-Claude Bradley Open Melting Point Dataset 17008, 17229, 22105, 27892, 27893, 27894, 27895 235.25 °C Jean-Claude Bradley Open Melting Point Dataset 27892, 27893, 27894, 27895
236 °C Jean-Claude Bradley Open Melting Point Dataset 27892, 27893, 27894, 27895
235 °C Jean-Claude Bradley Open Melting Point Dataset 6603 234–236 °C Alfa Aesar A10431, 39214 Experimental Boiling Point:
178 °C (Sublimes) Alfa Aesar 178 °C (Sublimes) Alfa Aesar 39214
28. Susan Budavari, ed. (1996). The Merck Index (12th ed.). Whitehouse Station, NJ: Merck & Co., Inc. p. 268.
29. This is the pKa for protonated caffeine, given as a range of values included in Prankerd RJ (2007). Brittain HG (ed.). “Critical Compilation of pK(a) Values for Pharmaceutical Substances”. Profiles of Drug Substances, Excipients, and Related Methodology. Academic Press. 33: 1–33 (15).
30. Klosterman L (2006). The Facts About Caffeine (Drugs). Benchmark Books (NY). p. 43
31. Vallombroso T (2001). Organic Chemistry Pearls of Wisdom. Boston Medical Publishing Corp. p. 43.
32. Keskineva N. “Chemistry of Caffeine” (PDF). Chemistry Department, East Stroudsburg University. Archived from the original (PDF) on 2 January 2014.
Retrieved 2 January 2014.
33. “Caffeine biosynthesis”. The Enzyme Database. Trinity College Dublin. Archived from the original on 22 March 2012. Retrieved 24 September 2011.
34. “MetaCyc Pathway: caffeine biosynthesis I”. MetaCyc database. SRI International. Archived from the original on 29 May 2018. Retrieved 12 July 2017. 35. Temple NJ, Wilson T (2003). Beverages in Nutrition and Health. Totowa, NJ: Humana Press. p. 172.
36. US patent 2785162, Swidinsky J, Baizer MM, “Process for the formylation of a 5-nitrouracil”, published 12 March 1957, assigned to New York Quinine and Chemical Works, Inc.
37. Denoeud F, Carretero-Paulet L, Dereeper A, Droc G, Guyot R, Pietrella M, et al. (September 2014). “The coffee genome provides insight into the convergent evolution of caffeine biosynthesis”. Science. 345 (6201): 1181–4.
38. Huang R, O’Donnell AJ, Barboline JJ, Barkman TJ (September 2016). “Convergent evolution of caffeine in plants by co-option of exapted ancestral enzymes”. Proceedings of the National Academy of Sciences of the United States of America. 113 (38): 10613–8
39. Williams R (21 September 2016). “How Plants Evolved Different Ways to Make Caffeine”. The Scientist.
40. Zajac MA, Zakrzewski AG, Kowal MG, Narayan S (2003). “A Novel Method of Caffeine Synthesis from Uracil” (PDF). Synthetic Communications. 33 (19): 3291–3297.
41. Tilling S. “Crystalline Caffeine”. Bristol University. Archived from the original on 5 August 2011. Retrieved 3 August 2009.
42. Senese F (20 September 2005). “How is coffee decaffeinated?”. General Chemistry Online. Archived from the original on 18 January 2012. Retrieved 3 August 2009.
43. McCusker RR, Fuehrlein B, Goldberger BA, Gold MS, Cone EJ (October 2006). “Caffeine content of decaffeinated coffee”. Journal of Analytical Toxicology. University of Florida News. 30 (8): 611–3.