Volume : 12, Issue : 08, August- 2025

Title:

FORMULATIONS AND EVALUATION OF SUSTAINED RELEASE TABLETS OF SITAGLIPTIN

Authors :

Neerudu Supriya, Jimidi Bhaskar*

Abstract :

Diabetes mellitus is a metabolic illness with many symptoms defined by long-lasting hyperglycemia and variations in carbohydrate, lipid, and protein metabolism caused by insulin release and action abnormalities. Sustained rekease type of drug delivery system includes any drug delivery that achieve sustained release of drug over an extended period of time. The goal of the following research work is to formulate, develop ad evaluate sustained release formulation for anti-diabetic by using various polymers and excipients to enhance gastric retention. The tablets were formulated using a direct compression method and evaluated for their physicochemical properties, in vitro buoyancy, and drug release profiles. The optimized formulation (F4) showed a satisfactory floating lag time, buoyancy, and sustained release of Sitagliptin over 24 h. The release kinetics followed a zero-order model, and the mechanism of drug release was found to be Fickian diffusion. The results suggest that the developed sustained release tablets of sitagliptin can potentially improve patient compliance and therapeutic efficacy.
Key words: Sustained release, sitagliptin, diabetes mellitus, glucose-dependent insulinotropic polypeptide, gastric retention, floating tablets

Cite This Article:

Please cite this article in press Jimidi Bhaskar et al., Formulations And Evaluation Of Sustained Release Tablets Of Sitagliptin., Indo Am. J. P. Sci, 2025; 12(08).

Number of Downloads : 10

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