07.Issue 12 december 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 12, December- 2025

Title:

PHYTOMEDICINES WITH ANTIBACTERIAL POTENTIAL: FORMULATION, MECHANISMS, AND CLINICAL PROSPECTS

Authors :

Pravina Pandurang Ayare*, Gadhire Dhanshree Baliram, Divya Mahadev Borade, Ghadage Swapnali Dhanaji, Prachiti Vasant Katkar, Gauri Shashikant Shete

Abstract :

The rising global challenge of antimicrobial resistance (AMR) has intensified the search for novel therapeutic alternatives with broader efficacy and enhanced safety profiles. Phytomedicines—bioactive formulations derived from medicinal plants—have gained significant attention due to their potent antibacterial activities, rich phytochemical diversity, and minimal side-effects compared to synthetic antibiotics. This review comprehensively discusses the antibacterial potential of phytomedicines by exploring their botanical sources, phytochemical constituents, pharmacognostic features, and physicochemical characteristics. The mechanisms of antibacterial action, including membrane disruption, enzyme inhibition, efflux pump suppression, and quorum-sensing interference, are elaborated in detail. The review further highlights advances in formulation strategies such as nanoemulsions, liposomes, phytosomes, hydrogels, and polymeric nanoparticles designed to improve solubility, stability, bioavailability, and targeted drug delivery. Pharmacological investigations, toxicity evaluations, traditional uses, and contemporary clinical prospects are presented along with an extensive literature survey. Overall, phytomedicines emerge as promising antibacterial agents capable of complementing or replacing conventional therapies, providing a valuable platform for the development of next-generation antimicrobial therapeutics.
Keywords: Phytomedicines, antibacterial activity, phytochemicals, microbial resistance, plant extracts, formulation strategies, mechanism of action, clinical applications, nanoformulations, ethnomedicine.

Cite This Article:

Please cite this article in press Pravina Pandurang Ayare et al., Phytomedicines With Antibacterial Potential: Formulation, Mechanisms, And Clinical Prospects, Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

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