Volume : 12, Issue : 10, October – 2025

Title:

EXPLORING THE THERAPEUTIC ROLE OF GLYCYRRHIZA GLABRA IN RESPIRATORY TRACT INFECTIONS: EFFICACY, MECHANISMS, AND SAFETY CONSIDERATIONS.

Authors :

Pallavi S. Gore , Aditi V.Tikait , Dr. Swati P. Deshmukh

Abstract :

Respiratory tract infections (RTIs) are among the most widespread health concerns globally, contributing significantly to morbidity and mortality. The rising resistance to conventional antibiotics and antiviral drugs has intensified the search for alternative therapies, particularly those derived from natural sources with established safety and efficacy profiles. Glycyrrhiza glabra (commonly known as licorice or mulethi) is a well-known medicinal plant traditionally used in Ayurveda, Unani, and Traditional Chinese Medicine for managing respiratory conditions.(1) Its therapeutic potential is largely attributed to its bioactive constituents, such as glycyrrhizin, glycyrrhetinic acid, and liquiritin, which demonstrate antiviral, antibacterial, anti-inflammatory, antioxidant, and immunomodulatory properties.(2) Multiple preclinical and clinical studies support its effectiveness in alleviating symptoms associated with RTIs, including cough, sore throat, bronchitis, and asthma. While generally safe at therapeutic doses, overuse may lead to adverse effects like pseudoaldosteronism and electrolyte imbalances due to the mineralocorticoid-like action of glycyrrhizin.(3) This review provides a comprehensive overview of the pharmacological actions, mechanisms, and safety considerations of G.glabra, emphasizing its potential role as a natural, effective adjunct to conventional therapies in the prevention and treatment of respiratory tract infections.
Keywords: Glycyrrhiza glabra, Licorice, Respiratory tract infections, Antiviral, Anti-inflammatory, Antioxidant, Safety, Pharmacology, Herbal medicine.(4)

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