Volume : 13, Issue : 07, July – 2026
Title:
MULTIPLE EMULSION DRUG DELIVERY SYSTEMS: FORMULATION STRATEGIES, CHARACTERIZATION, AND PHARMACEUTICAL APPLICATIONS
Authors :
Vaibhav S. Sahare, Mohd Bilal Sufi, Mudabbirul Haque
Abstract :
Multiple emulsion drug delivery systems are advanced colloidal carriers designed to encapsulate both hydrophilic and lipophilic drugs within a single formulation, enabling controlled and sustained drug release. The two principal types, water-in-oil-in-water (W/O/W) and oil-in-water-in-oil (O/W/O), improve drug stability, bioavailability, and therapeutic efficacy while reducing dosing frequency and enhancing patient compliance. Formulation performance is influenced by the selection of oils, surfactants, polymers, co-surfactants, and preparation techniques such as two-step emulsification, membrane emulsification, ultrasonication, and high-pressure homogenization. Characterization parameters including droplet size, pH, viscosity, drug content, entrapment efficiency, in vitro drug release, and stability are essential for ensuring formulation quality and performance. Multiple emulsions have demonstrated significant potential in topical, oral, transdermal, ocular, and targeted drug delivery, particularly for antifungal, anti-inflammatory, anticancer, and cosmetic applications. Despite challenges related to physical stability and large-scale manufacturing, continued technological advancements are expected to expand their pharmaceutical and commercial applications.
Keywords: Multiple emulsion, W/O/W emulsion, O/W/O emulsion, Controlled drug release, Drug delivery system, Entrapment efficiency, Pharmaceutical applications, Formulation strategies, Characterization, Sustained release.
Cite This Article:
Please cite this article in press Vaibhav S. Sahare et al., Multiple Emulsion Drug Delivery Systems: Formulation Strategies, Characterization, And Pharmaceutical Applications, Indo Am. J. P. Sci, 2026; 13(07).
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