Volume : 13, Issue : 10, October – 2026
Title:
EVALUATION OF ANTI ASTHMATIC ACTIVITY OF CAPPARIS DECIDUA IN ANIMAL MODELS
Authors :
K Apoorva*, Ch. Sunitha
Abstract :
Asthma is a chronic disease that affects approximately 300 million people worldwide. Although wide range of drug is available, the relief provided by them is mainly symptomatic and short lived. Moreover, the side effects of these drugs are also quite disturbing. Hence, a continuous search is on going to identify effective and safe remedies to treat bronchial asthma. Ayurveda is a great Indian tradition and have an important role in discovery of new medicines. There are many natural herbs that can be used for asthma, treatment. Capparis deciduas is traditionally used to treat asthma.
Objective: Although these plants possess diverse pharmacological actions, the scientific data on anti-asthmatic actions of this plant has got little attention. An attempt has been made to evaluate antiasthamatic activity of Capparis deciduas of aqueous and alcoholic extracts of medicinal plant.
Materials and methods: Different groups of guinea pigs (350-500 g) of either sex were subjected to acetylcholine (n = 5) and histamine-induced (n = 10) airway constriction.
Results: AQECD and ALECD (200 and 300 mg/kg) showed potent bronchodilator activity on histamine-and acetylcholine-induced airway constriction in guinea pigs. These extract has shown the sub-effective dose produced at 100, 200 and 300 mg/kg in all the models. The LD50 of the Aqueous and Alcoholic extracts at a dose of 100, 200 and 300 mg/kg are found to be 2262.7 and 1131.4 by oral route. These LD50 values fall within the practically non-toxic range.
Discussion and conclusion: The present study for the first time indicates anti-asthmatic, acute, sub-acute studies of Capparis deciduas medicinal plants, confirming their traditional claims. The anti-asthmatic action of Capparis deciduas could be due to the inhibition of the synthesis, release or action of histamine and acetylcholine effect.
Keywords: Antiasthmatic, Capparis deciduas, Histamine-induced model and Acetylcholine induced model.
Cite This Article:
Please cite this article in press K Apoorva et al., Evaluation Of Anti Asthmatic Activity Of Capparis Decidua In Animal Models.,. Indo Am. J. P. Sci, 2026; 13(10).
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